Inflammation is the biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells or irritants. One of the major intracellular regulators of inflammation is the transcription factor NF-B which upregulates the expression of cytokines. Chronic inflammation can lead to various diseases, such as Alzheimer’s disease, autoimmune disorders and cancer.
Inflammasomes represent high molecular weight complexes that activate inflammatory caspases and activate cytokines of the IL-1 family (IL-1b, IL-18). Inflammasomes can be activated through multiple signals including live bacteria, microbial toxins, xeno-compounds, PAMPs and DAMPs. Inflammasomes play an important role in several diseases, such as gout and Type 2 Diabetes Mellitus (T2DM) and contributes to insulin resistance.
AdipoGen is a main supplier of key inflammasome research reagents, including ELISA Kits, Antibodies (monoclonal, polyclonal and recombinant), Recombinant Proteins and Small Molecules focusing on: